Get Your Kicks on Route 66 With a convenient location along historic Route 66 at the junction of highways I-44 and I-270, our Holiday Inn has the best to offer to our guests in accommodations. Our hotel is centrally located to everything St. Louis has to offer and is just minutes from the top attractions in the area. We are just 14 miles from theGateway Archand all downtown sporting and fun attractions. The hotel is in Sunset Hills and less than two miles from the Historic Kirkwood. Stay and play in St. Louis, experience aSt. Louis Cardinalsgame at Busch Stadium, a St. Louis Blues hockey game at Enterprise Arena, visitThe St. Louis Zoo, Science Center, the St. Louis Aquarium, Missouri Botanical Gardens, Magic House, Six Flags,World Wide Technology Soccer Park. The hotel is a short drive to Webster University, Harris-Stowe, St. Louis University and Washington University's top medical centers, Barnes Jewish Hospital, St. Louis Children's Hospital, SSM, and Mercy Hospitals. We welcome corporate and leisure travelers to our 213-room hotel with 18,000 square feet of flexible space available for your next event. Our Sunset Event Space, operated by Twisted Catering, will be the place to book your wedding or special event. Guests can enjoy lunch or dinner at Award-winning Twisted Tree Steakhouse adjacent to the hotel. Enjoy "Wakey Wakey a Breakfast Place" now open for a fresh start your day.