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Welcome to Best Western Plus The Charles Hotel! The location of our St. Charles MO hotel makes all the difference because we’re near the casino, next to the business park, the Bass Pro Shop is next door and we’re right off of Interstate 70. With the Hollywood Casino Amphitheater nearby and the Family Arena minutes away, guests at our St. Charles, MO hotel are close to it all. Stay close to historic Main Street to make the most of your trip. Whether guests are looking for a hotel near Ameristar Casino or a hotel near Earth City Business Park, we have the ideally situated property for you. Our St. Charles, MO hotel is designed with your comfort in mind. For those looking for hotels near Historic St. Charles, MO and Main Street, you’ll be within walking distance to the best the city has to offer. Visiting St. Louis, MO? We are 18 miles west. However, the abundance of business in the area also brings a number of business travelers to our property. From leisure to important meetings, we cater to all visitors. The St. Charles Convention Center has events happening year-round, and the Katy Trail is a popular bike trail that draws outdoor lovers and cyclists to the region. Whether you’re here for Bayer or a lecture at Lindenwood University, where you stay matters. Our St. Charles, MO hotel is a home away from home for UPS employees, and is a spacious retreat for those who are here for a loved one’s graduation on campus. The city of St. Charles boasts Missouri’s oldest historic waterfront district and features more than 125 retail and restaurant venues. With 225 miles of railway turned biking and hiking on Katy Trail, there’s also plenty of opportunity to enjoy all that Mother Nature has to offer in this gorgeous region. Book your next stay at Best Western Plus The Charles Hotel for the friendliest service in town! Enjoy your stay. Pets are not allowed in suites. Trash/towel service daily. Full housekeeping is offered after the third night.