discover Central California's San Joaquin Valley. welcome to the Hampton Inn & Suites – Fresno/Highway 99 CA. Hampton Inn & Suites Fresno hotel is conveniently located in the Northwest part of the city off of Highway 99 and Herndon Ave. During your stay with us, you’ll enjoy easy access to many amazing destinations in the Central Valley, such as Yosemite National Park, Sequoia National Park, Fresno Yosemite International Airport, Fresno State University, the Madera Wine Trail, and much more. Love to shop? Our Fresno, CA hotel is mere minutes from the River Park Shopping and Entertainment Center, Fashion Fair Mall, and Downtown Fresno. Fresno is also the center of agriculture, business, finance, art, and entertainment in the San Joaquin Valley. If you’re here on business, you’ll be close to the Fresno Convention and Entertainment Center, as well as local companies like JEM Management Corp; Harris Ranch, West Air, Inc; Sun-Maid and more. No matter what brings you to our Fresno, California hotel, you’ll enjoy beautiful year-round weather, many outdoor adventures, and a location close to it all! Visit the Hampton Inn & Suites and discover Central California's San Joaquin Valley.