Good if you like central location
The location is very central, lots of restaurants and other facilities near by. Easy to get to Sultanahmet to see the sights. The rooms are good for the price. The economy room is very small, which is ok if you don't intend to stay in the hotel much. The staff is friendly and helpful.
The windows are not well noise isolated, so if you have problems sleeping with noise you won't like the hotel. The staff had problems receiving the payment via the system used by hotels.com and asked that we would pay directly, which we refused. Later they were able to transfer the payment. This left me with a nasty feeling (perhaps unfounded) that they were trying to get the payment twice.
With a stay at Serene Hotel Istanbul in Istanbul (Taksim), you'll be steps from Istiklal Avenue and 10 minutes by foot from Taksim Square. Featured amenities include dry cleaning/laundry services, multilingual staff, and luggage storage. A roundtrip airport shuttle is provided for a surcharge (available on request).