Stay Your Way at the Holiday Inn Express and Suites in St. Charles MO Hotels. Located in the charming Historic St. Charles City just 30 miles from downtown St. Louis and minutes from the confluence of the Missouri and Mississippi rivers. Our location off Highway 370 just 4.5 miles from Historic St. Charles is perfect for people traveling for business or pleasure. While St. Charles has history, charm and attractions to entertain you for days, St. Louis is also a hotbed of activity. Our St. Charles hotel is not far from attractions like the St. Louis Zoo, the Baseball Cardinals Busch Stadium, Gateway Arch Riverfront and more. Our St. Charles hotel's location is also near the Ameristar and Hollywood Casinos if you wish to try your luck at the slots. When you stay at our hotel in St. Charles, you have easy access to St. Louis and the St. Louis Airport and to several major business corridors. Our St. Charles hotel's 24-hour Business Center is equipped with a printer and PC, and our free high-speed Internet access keeps you easily connected. Our hotel in St. Charles is full of great amenities that everyone can enjoy. You can work up a sweat in the 24-hour Fitness Center, swim in the indoor pool and indulge in a delicious complimentary, hot breakfast bar. Make sure to book a room today to take advantage of everything we offer.